Le-Nutra uses the latest technology to produce Calcium AKG which meets international standards, ensuring that each batch is of high and stable quality. We use carefully selected natural raw materials and undertake strict testing and quality control to ensure the active components of our products. Furthermore, we utilize high-temperature sterilization technology during production not only preserves the integrity of active ingredients but also effectively eliminates potentially harmful microorganisms, offering you a safer, more reliable product.

1. With over 10 years of experience in research and production in the industry, our excellent technical team with professional skills ensures that we meet the different needs of customers for content.

2. A professional service team will solve customer problems timely and supply reasonable solutions according to each customer's needs.

3. Our primary focus extends across the European and American regions, a testament not only to our commitment to product excellence but also to our recognized leadership within the field.

4. Safe and reliable logistics and distribution, we provide flexible delivery times and quickly respond to customers' different needs for transportation services.

Calcium AKG powder, a stable natural substance, presents as a white crystalline powder that is essentially insoluble in water. Derived from -ketoglutarate (AKG), which is naturally produced by our bodies until around age 40 before experiencing a significant decline, CaAKG holds pivotal roles in various bodily functions. Initially synthesized during cellular energy production, AKG serves as the nitrogen-free component of glutamine and glutamic acid, fueling cellular activity and safeguarding overall health throughout the aging process. It plays a crucial role in supporting cellular repair, particularly in injured muscle tissue, while also contributing to digestive and kidney function, as well as bone tissue development. CaAKG is naturally present in a range of foods, including beef, eggs, tofu, skim milk, and various grains and vegetables. With its potential to prevent osteoporosis, stabilize the immune system, aid in weight management, and regulate aging processes, CaAKG holds significant promise across multiple domains, including medical treatment, cosmetic formulations, and health products.

To promote gastrointestinal health, Calcium AKG (CaAKG) are recognized for their anti-catabolic properties, effectively slowing or preventing tissue breakdown. Studies have indicated that rats supplemented with CaAKG maintained normal growth even when their diet lacked protein entirely, with higher doses yielding more favorable outcomes. Research findings corroborate the anti-catabolic effects of alpha-ketoglutarate. Furthermore, CaAKG facilitates metabolism, particularly by bolstering amino acid metabolism. Its ability to mitigate hyperphosphatemia contributes to reduced ammonia levels within cells, alleviating conditions like muscle cramps associated with elevated blood phosphate levels. Metabolism and aging are intricately linked, and a robust metabolism supports overall health and longevity. Lifespan extension is also a potential benefit of CaAKG supplementation, with studies demonstrating a reported 12% increase in lifespan during aging studies. Notably, while the reduction in morbidity surpasses the increase in lifespan, CaAKG has been shown to partially extend lifespan and enhance overall quality of life in later stages of aging. Moreover, CaAKG aids in restoring normal calcium levels in the blood by binding to excess phosphate, thus restoring the balance between phosphate and calcium levels. Positive outcomes have been observed in patients with hyperparathyroidism, where CaAKG supplementation effectively reduces blood phosphate levels and elevates calcium levels, promoting optimal physiological functioning.

In terms of production, CaAKG is typically derived from -ketoglutarate through salt formation with calcium chloride under appropriate conditions. Various preparation methods exist, including chemical synthesis, microbial fermentation, and enzyme catalytic conversion. While chemical synthesis presents challenges due to the use of organic solvents and potential genotoxicity concerns, microbial fermentation and enzyme catalytic conversion methods offer environmentally friendly, energy-efficient, and high-yield alternatives, thus gaining prominence in the market, particularly in food-grade applications.